It has been shown that inhibition of a key chromatin remodeling complex known as NuRD, by deleting one of its subunits, can result in a significant increase in the efficiency of reprogramming of somatic cells into pluripotent stem cells. The reprogramming is normally done by the induced expression of a battery of transcription factors in the somatic cells, but is typically not very efficient. Such an observation suggests that the NuRD complex is normally involved in …

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The NuRD chromatin remodeling complex is thought to be normally involved in maintaining the repressive epigenetic state of several developmentally important genes in the somatic cells, thus resisting the pluripotency induction and preventing efficient reprogramming of these cells into stem cells. Inhibition of this complex relieves this repression, allowing a more efficient reprogramming.

It Has Been Shown That Inhibition of a Key Chromatin