How does a eukaryotic cell deal with the superhelical tension in its genomic DNA resulting from the activity of RNA polymerases?
A) DNA gyrase introduces negative supercoils, keeping the DNA under constant tension.
B) The RNA polymerases are allowed to rotate freely around their templates during transcription, leading to the relaxation of the tension.
C) DNA topoisomerases rapidly remove the superhelical tension caused by transcription.
D) The nucleosomes adjust the tension by binding to positively supercoiled regions behind a moving RNA polymerase.
E) All of the above.

Question

Quizplus · Accepted Answer

Unlike bacteria, which maintain a fairly constant level of negative supercoiling in their circular DNA, eukaryotic topoisomerases rapidly remove the superhelical tension caused by DNA translocating machines such as the RNA polymerases.

How Does a Eukaryotic Cell Deal with the Superhelical Tension