Which of the following better describes a typical, actively translated mRNA in its journey from the nucleus to the cytosol?
A) Initially in a circular conformation, the mRNA linearizes, enters the cytosol (5' end first), and remains linear.
B) Initially in a circular conformation, the mRNA linearizes, enters the cytosol (3' end first), and remains linear.
C) Initially linear, the mRNA enters the cytosol (5' end first), and adopts a circular conformation.
D) Initially linear, the mRNA enters the cytosol (3' end first), and adopts a circular conformation.
E) Initially linear, the mRNA enters the cytosol (3' end first), and remains linear.

Question

Quizplus · Accepted Answer

Normally, the export of an mRNA to the cytosol occurs with the 5' cap proceeding first. The mRNA can then circularize through the interaction of the cytosolic cap-binding proteins with the cytosolic poly-A-binding proteins to facilitate rapid translation.

Which of the Following Better Describes a Typical, Actively Translated