Indicate true (T) and false (F) statements below regarding mRNA stability and degradation. Your answer would be a four-letter string composed of letters T and F only, e.g. TTFT.
( ) Any factor that affects the translation efficiency of an mRNA tends to have the opposite effect on its degradation.
( ) Decapping of mRNA normally occurs after poly-A tail shortening removes the poly-A tail and starts chewing into the 3?-UTR.
( ) Most mRNA decay in the cells generally proceeds via endonucleolytic cleavage.
( ) As a general rule, eukaryotic mRNAs have a shorter half-life compared to bacterial mRNAs.

Question

Indicate true (T) and false (F) statements below regarding mRNA stability and degradation. Your answer would be a four-letter string composed of letters T and F only, e.g. TTFT.
( )	Any factor that affects the translation efficiency of an mRNA tends to have the opposite effect on its degradation.
( )	Decapping of mRNA normally occurs after poly-A tail shortening removes the poly-A tail and starts chewing into the 3?-UTR.
( )	Most mRNA decay in the cells generally proceeds via endonucleolytic cleavage.
( )	As a general rule, eukaryotic mRNAs have a shorter half-life compared to bacterial mRNAs.

Quizplus · Accepted Answer

Eukaryotic mRNAs are generally more stable than bacterial mRNA. Eukaryotic mRNA decay is mediated by 5? exonucleases (after decapping) or 3? exonucleases, usually after poly-A tail shortening leaves only about 25 nucleotides of the tail. Since the poly-A shortening and the translation machinery compete for the same components, factors that affect one of them also affect the other one in an opposite direction. Some mRNAs are destroyed by specific endonucleases.

Indicate True (T) and False (F) Statements Below Regarding MRNA