Consider the descriptions below for three different lncRNAs, and determine whether they function in cis (C) or in trans (T). Your answer would be a three-letter string composed of letters C and T only, e.g. CCT.
( ) The tsiX RNA is transcribed from the X-inactivation center in the X chromosome that will not be inactivated. It is antisense with respect to Xist, repressing its transcription and function.
( ) The ANRIL lncRNA is an antisense transcript in a gene cluster expressing inhibitors of cell-cycle proteins. It silences the entire cluster by recruiting heterochromatin proteins of the Polycomb group.
( ) The PTENP1 lncRNA is similar to an mRNA that encodes the protein PTEN, and contains many of the miRNA response elements present in PTEN mRNA; it therefore protects the PTEN mRNA from miRNA-mediated silencing by acting as a decoy.

Question

Consider the descriptions below for three different lncRNAs, and determine whether they function in cis (C) or in trans (T). Your answer would be a three-letter string composed of letters C and T only, e.g. CCT.
( )	The tsiX RNA is transcribed from the X-inactivation center in the X chromosome that will not be inactivated. It is antisense with respect to Xist, repressing its transcription and function.
( )	The ANRIL lncRNA is an antisense transcript in a gene cluster expressing inhibitors of cell-cycle proteins. It silences the entire cluster by recruiting heterochromatin proteins of the Polycomb group.
( )	The PTENP1 lncRNA is similar to an mRNA that encodes the protein PTEN, and contains many of the miRNA response elements present in PTEN mRNA; it therefore protects the PTEN mRNA from miRNA-mediated silencing by acting as a decoy.

Quizplus · Accepted Answer

C
T
 The first two lncRNAs act in cis; i.e. they affect only the chromosome from which they are transcribed. The third example, however, acts in trans and regulates the function of other genes after it diffuses from its site of synthesis.

Consider the Descriptions Below for Three Different LncRNAs, and Determine