According to the model for nuclear transport described in this chapter, what do you think would happen if you could artificially limit all Ran-GAP activity to the nucleus and all Ran-GEF activity to the cytosol?
A) Proteins containing an NLS would be actively exported from the nucleus, while NES-containing proteins would be actively imported.
B) Both import and export of nuclear proteins would be stalled, as they lose their directionality.
C) Protein import into the nucleus would be reversed, but export would be unaffected.
D) Protein import into the nucleus would be stalled, but export would be unaffected.
E) Nothing would change; this is the normal Ran-GAP and Ran-GEF distribution.

Question

Quizplus · Accepted Answer

The directionality of nuclear protein transport pathways relies on the asymmetrical distribution of the two conformations of Ran GTPase, which in turn depends on the activities of nuclear Ran-GEFs and cytosolic Ran-GAPs. Reversing the locations of these activities would reverse the direction of the transport pathways.

According to the Model for Nuclear Transport Described in This