Indicate whether each of the following descriptions better matches the ATF6 (A), the IRE1 (I), or the PERK (P) branch of the ER unfolded protein response. Your answer would be a four-letter string composed of letters A, I, and P only, e.g. APII.
( ) It involves a noncanonical cytoplasmic splicing process.
( ) Its sensor is a latent transcription regulator.
( ) It involves regulated proteolysis of the sensor protein in the Golgi apparatus.
( ) Its sensor bears both kinase and endoribonuclease activities.

Question

Indicate whether each of the following descriptions better matches the ATF6 (A), the IRE1 (I), or the PERK (P) branch of the ER unfolded protein response. Your answer would be a four-letter string composed of letters A, I, and P only, e.g. APII.
( )	It involves a noncanonical cytoplasmic splicing process.
( )	Its sensor is a latent transcription regulator.
( )	It involves regulated proteolysis of the sensor protein in the Golgi apparatus.
( )	Its sensor bears both kinase and endoribonuclease activities.

Quizplus · Accepted Answer

Upon regulated proteolytic cleavage, the released ATF6 fragment enters the nucleus and alters the expression of its target genes. The IRE1 protein is a kinase/endoribonuclease that regulates the splicing of a transcription regulatory protein.

Indicate Whether Each of the Following Descriptions Better Matches the ATF6