A protein is covalently attached to glycosylphosphatidylinositol. Which of the following is typically NOT true regarding this protein?
A) The linkage of the anchor to the C-terminus of the protein occurs in the ER.
B) The attachment of the anchor coincides with cleavage of a C-terminal transmembrane segment of the protein precursor.
C) The protein is likely to be an ER resident, helping with the folding of nascent imported proteins.
D) A phospholipase can cleave the protein from the membrane.
E) The anchor affects the localization of the protein in the membrane.

Question

Quizplus · Accepted Answer

GPI-anchored proteins are made in the endoplasmic reticulum and almost exclusively found on the extracellular leaflet of the plasma membrane.

A Protein Is Covalently Attached to Glycosylphosphatidylinositol