Aspartic acid residues resemble phosphorylated serine residues in proteins and also carry a similar negative charge. As a result, a protein in which serine residues are mutated to aspartic acid residues may mimic the function of the corresponding wild-type protein when those serines are phosphorylated. Given that phosphorylation on serine residues in a number of Golgi matrix proteins occurs during mitosis, would you expect that mutation of these serines to aspartic acids would prevent Golgi stack formation in interphase (1) or prevent Golgi dispersion in mitosis (2)? Write down 1 or 2 as your answer.

Question

Quizplus · Accepted Answer

The mutant proteins mimic constitutively phosphorylated proteins, and therefore recapitulate the mitotic Golgi fragmentation even in interphase.

Aspartic Acid Residues Resemble Phosphorylated Serine Residues in Proteins and Also