Indicate whether each of the following membrane proteins releases its protein ligand (R), remains bound to its protein ligand (B), or is degraded in the lysosome along with its protein ligand (D) following receptor-mediated endocytosis. Your answer would be a three-letter string composed of letters R, B, and D only, e.g. RBD.
( ) LDL receptor
( ) Transferrin receptor
( ) EGF receptor

Question

Indicate whether each of the following membrane proteins releases its protein ligand (R), remains bound to its protein ligand (B), or is degraded in the lysosome along with its protein ligand (D) following receptor-mediated endocytosis. Your answer would be a three-letter string composed of letters R, B, and D only, e.g. RBD.
( )	LDL receptor
( )	Transferrin receptor
( )	EGF receptor

Quizplus · Accepted Answer

LDL receptors release LDL in the low pH in early endosomes and are recycled back to the cell surface. Transferrin receptors do not release transferrin in early endosomes: the low pH only results in the release of the bound iron, and the transferrin-receptor complex is recycled. In contrast, most EGF receptors are not recycled and are degraded in the lysosomes along with EGF.

Indicate Whether Each of the Following Membrane Proteins Releases Its