Indicate true (T) and false (F) statements below regarding receptor-mediated endocytosis of LDL particles. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) LDL receptors are normally degraded in the lysosome along with their LDL ligands.
( ) LDL receptors that do not bind to extracellular LDL cannot be internalized in clathrin-coated vesicles.
( ) A mutation that impairs the attachment of an LDL receptor to a clathrin-coated pit would cause depletion of blood LDL levels.
( ) LDL receptors at the plasma membrane are usually concentrated in clathrin-coated pits.

Question

Indicate true (T) and false (F) statements below regarding receptor-mediated endocytosis of LDL particles. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	LDL receptors are normally degraded in the lysosome along with their LDL ligands.
( )	LDL receptors that do not bind to extracellular LDL cannot be internalized in clathrin-coated vesicles.
( )	A mutation that impairs the attachment of an LDL receptor to a clathrin-coated pit would cause depletion of blood LDL levels.
( )	LDL receptors at the plasma membrane are usually concentrated in clathrin-coated pits.

Quizplus · Accepted Answer

Low-density lipoprotein (LDL) receptors associate with clathrin-coated pits and are internalized irrespective of ligand binding. They normally release their bound LDL (if any) in the early endosomes and are recycled back to the plasma membrane. Mutations that interfere with receptor-mediated endocytosis of LDL particles can cause high blood cholesterol and lead to diseases such as atherosclerosis.

Indicate True (T) and False (F) Statements Below Regarding Receptor-Mediated