Sort the following events to reflect the order in which they occur during engulfment of an antibody-coated microorganism by a neutrophil in the blood. Your answer would be a four-letter string composed of letters A to D only, e.g. DACB.
(A) Rho-GEF activation
(B) Activation of Fc receptors
(C) Local PI(4,5)P? production
(D) Local PI(3,4,5)P? production

Question

Sort the following events to reflect the order in which they occur during engulfment of an antibody-coated microorganism by a neutrophil in the blood. Your answer would be a four-letter string composed of letters A to D only, e.g. DACB.
(A)	Rho-GEF activation
(B)	Activation of Fc receptors
(C)	Local PI(4,5)P? production
(D)	Local PI(3,4,5)P? production

Quizplus · Accepted Answer

The ordered generation and conversion of phosphoinositides guides sequential steps of phagocytosis. First, PI(4,5)P? is produced by a kinase to induce actin polymerization and engulfment of the target particle. Then, another kinase converts PI(4,5)P? to PI(3,4,5)P?, which is required for the closure of the phagosome.

Sort the Following Events to Reflect the Order in Which