Indicate true (T) and false (F) statements below regarding cancer. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( ) Cancers become less and less heterogeneous as they progress.
( ) Knocking out Ras or Myc genes individually leads to a higher incidence of cancers in mice, and knocking out both genes simultaneously has an even stronger phenotype.
( ) Wnt signaling is important in colon epithelial cells and, correspondingly, mutations in genes in the Wnt pathway are present in most colorectal cancers.
( ) Genome destabilization in a subset of colorectal cancers that have defects in DNA mismatch repair takes the form of chromosome breaks, translocations, and deletions.

Question

Indicate true (T) and false (F) statements below regarding cancer. Your answer would be a four-letter string composed of letters T and F only, e.g. TFFF.
( )	Cancers become less and less heterogeneous as they progress.
( )	Knocking out Ras or Myc genes individually leads to a higher incidence of cancers in mice, and knocking out both genes simultaneously has an even stronger phenotype.
( )	Wnt signaling is important in colon epithelial cells and, correspondingly, mutations in genes in the Wnt pathway are present in most colorectal cancers.
( )	Genome destabilization in a subset of colorectal cancers that have defects in DNA mismatch repair takes the form of chromosome breaks, translocations, and deletions.

Quizplus · Accepted Answer

Cancer risk is increased by gain-of-function mutations in Ras and Myc, not by their knockout. It is not surprising that in cancer cells with defects in DNA mismatch repair, many point mutations are found throughout the genome. Cancer progression coincides with increasing heterogeneity of the tumor cell population.

Indicate True (T) and False (F) Statements Below Regarding Cancer