The following simplified diagram shows the typical sequence of genetic changes in a developing colorectal carcinoma. Indicate which event (A to C) corresponds to the following changes. Your answer would be a three-letter string composed of letters A to C only, e.g. CAB.

( ) Activation of K-Ras
( ) Loss of p53
( ) Loss of Apc

Question

The following simplified diagram shows the typical sequence of genetic changes in a developing colorectal carcinoma. Indicate which event (A to C) corresponds to the following changes. Your answer would be a three-letter string composed of letters A to C only, e.g. CAB.
  
( )	Activation of K-Ras
( )	Loss of p53
( )	Loss of Apc

Quizplus · Accepted Answer

This oversimplified diagram provides a general correspondence between mutations and the stages of cancer progression. In most cases, inactivating Apc mutations appear to occur early, followed by later activation of K-Ras and inactivation of p53. Many other mutations are generally involved. Note that genetic and epigenetic instability rises during the process.

The Following Simplified Diagram Shows the Typical Sequence of Genetic