Which of the following conditions is NOT expected to provide protection against HIV-1 infection of helper T cells?
A) A loss-of-function mutation in the CCR5 gene
B) Treatment with enfuvirtide, a membrane-fusion inhibitor
C) Treatment with concanamycin A, an inhibitor of endosomal proton pumps
D) Treatment with AMD-070, a CXCR4 antagonist
E) Treatment with PRO-542, a soluble decoy protein containing CD4 sequences

Question

Quizplus · Accepted Answer

Loss-of-function mutations in the co-receptor CCR5 can result in less susceptibility to human immunodeficiency virus (HIV) infection. Additionally, inhibition of membrane fusion, inhibition of the co-receptor CXCR4, or saturation of the viral envelope surface protein with soluble CD4 decoys can help limit viral entry. HIV can fuse with the plasma membrane at neutral pH, and increasing endosomal pH does not inhibit HIV infection.

Which of the Following Conditions Is NOT Expected to Provide