Which of the following statements accurately describes the relationship between energy restriction and longevity?
A) Improvements in longevity depend on reducing energy intake and not on the amount of body fat.
B) Restriction of energy intake in genetically obese animals does not seem to improve longevity.
C) Biochemical markers for longevity in humans are improved only when energy intake is reduced by at least one third.
D) The activities of the genes of older mice on energy-restricted diets are similar to those of mice on standard diets.
E) Research with humans has found a substantial increase in longevity, with a 5% reduction in energy intake.
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