Passage
When present in the bloodstream above a threshold partial pressure, a general anesthetic blocks the sensation of pain, induces a state of unconsciousness, and causes muscle paralysis. Many anesthetic agents are administered in their gaseous phase and are absorbed into the bloodstream through the lungs. The rate of diffusion Vgas of an anesthetic across the alveolar membrane with a surface area A and a thickness T is described by the Fick law of diffusion:
Vgas=DAΔPTEquation 1where D is the diffusion coefficient specific for the gas and ΔP is the partial pressure difference across the membrane.An inhaled anesthetic is described by its blood-gas partition coefficient, the ratio of the anesthetic's concentration in the blood to its concentration in the lungs when the partial pressures are equal. The concentration C of an anesthetic gas dissolved in blood is described by the Henry law of solubility:
C=kHPgasEquation 2where kH is the solubility constant specific for the gas and Pgas is the partial pressure of the gas.Due to the paralytic effects of general anesthetics, mechanical ventilators are usually necessary to assist a patient's breathing during surgery. Positive-pressure ventilators are noninvasive and use external pumps to induce inspiration by forcing air into the lungs through a ventilation mask. Despite the paralytic effects of general anesthesia, patients are often capable of expiration without the active aid of a mechanical ventilator.
-Many inhalational anesthetics are thought to increase surface tension effects in the alveoli. Water with greater surface tension:
A) climbs farther in a narrow glass tube.
B) evaporates more quickly.
C) has weaker van der Waals forces.
D) creates droplets with smaller surface areas.
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