Consider the two key roles that have been identified for SRP RNA. You have isolated a mutant SRP RNA. This RNA is able to perform its role as a scaffold for SRP proteins, but has lost its other function. How will this affect translation of SRP-containing proteins?
A) Partially translated proteins will be stuck in the cytosol.
B) Partially translated proteins will be stuck in the ER lumen.
C) Partially translated proteins will be stuck in the nucleus.
D) Translation will proceed normally.

Question

Quizplus · Accepted Answer

SRP RNA has two key roles: acting as a scaffold for SRP proteins and pausing translation to allow the ribosome-protein complex to dock to the ER. If it loses the latter function, partially translated proteins that should be directed to the ER will remain in the cytosol.

Consider the Two Key Roles That Have Been Identified for SRP