A 6-year-old African American youngster is brought to the doctor because he is easily fatigable. Splenomegaly is discovered on physical examination, and his complete blood count confirms slight anemia. On a cellulose acetate strip, hemoglobin electrophoresis is conducted at an alkaline pH. The patient's results are displayed below in comparison to those with normal hemoglobin and known sickle cell illness. Which of the following is the most likely cause of this patient's condition?

Question

A 6-year-old African American youngster is brought to the doctor because he is easily fatigable. Splenomegaly is discovered on physical examination, and his complete blood count confirms slight anemia. On a cellulose acetate strip, hemoglobin electrophoresis is conducted at an alkaline pH. The patient's results are displayed below in comparison to those with normal hemoglobin and known sickle cell illness.  Which of the following is the most likely cause of this patient's condition?

Quizplus · Accepted Answer

Eductional Objective: Hemoglobin C is produced by a missense mutation in which a glutamate residue in the beta globin chain is replaced by lysine. As a result, the hemoglobin molecule's total negative charge decreases. During gel electrophoresis, hemoglobin A moves faster than hemoglobin S and slower than hemoglobin C.

A 6-Year-Old African American Youngster Is Brought to the Doctor