A case-control research was carried out to determine the relationship between simvastatin medication and fibrinogen levels in patients undergoing percutaneous coronary intervention. Cases were defined as patients who had percutaneous coronary intervention and had high periprocedural fibrinogen levels (400 mg/dL), whereas controls were defined as patients who had percutaneous coronary intervention but had normal fibrinogen levels (200-400 mg/dL). Every patient's history of simvastatin medication was reviewed in detail. The table below shows the number of patients who met each of the categorization criteria. Which of the following is the best statistical method to estimate the association between simvastatin use and high serum fibrinogen levels in this study?

Question

A case-control research was carried out to determine the relationship between simvastatin medication and fibrinogen levels in patients undergoing percutaneous coronary intervention. Cases were defined as patients who had percutaneous coronary intervention and had high periprocedural fibrinogen levels (>400 mg/dL), whereas controls were defined as patients who had percutaneous coronary intervention but had normal fibrinogen levels (200-400 mg/dL). Every patient's history of simvastatin medication was reviewed in detail. The table below shows the number of patients who met each of the categorization criteria.  Which of the following is the best statistical method to estimate the association between simvastatin use and high serum fibrinogen levels in this study?

Quizplus · Accepted Answer

Eductional Objective: A 2 × 2 table is normally used to record the presence or absence of exposure and disease in research.  Rows and columns represent the different levels for each categorical (ie, exposure and disease) variable.  The chi-square test for independence is used to evaluate the association between 2 categorical variables.

A Case-Control Research Was Carried Out to Determine the Relationship