A 20-year-old man falls while strolling across a college campus. A passerby notices him to be unresponsive and pulseless. Despite the efforts of emergency medical experts, the man cannot be revived. In the weeks immediately up to the tragedy, his acquaintances claim he seemed weary and mentioned palpitations and dyspnea with exercise. He had no known medical history and did not smoke, drink, or use illegal substances. The man's three younger siblings are all ok. His parents confirm a paternal grandfather's history of "early cardiac illness" and want an autopsy and genetic tests for further study. A deficiency in a TTN gene exon results in a shortened titin protein, according to genetic research. Autopsy findings are most likely to show which of the following phenotypes?

Question

Quizplus · Accepted Answer

Eductional Objective: The most prevalent cause of familial dilated cardiomyopathy is autosomal dominant mutations in the TTN gene, which encodes for the sarcomere protein titin.

A 20-Year-Old Man Falls While Strolling Across a College Campus