A 54-year-old man visits his doctor complaining of new onset minor headaches and left leg weakness. The lesions discovered during a physical examination are depicted in the figure below. Which of the following inheritance patterns is most likely to be present in this patient's disorder?

Question

Quizplus · Accepted Answer

Eductional Objective: The picture shows cutaneous neurofibromas, which are fleshy, dome-shaped, or pedunculated lesions that are a feature of neurofibromatosis type 1. (NF-1). A mutation in the NF1 gene on chromosome 17 causes this autosomal dominant disease.
NF-1 has a high penetrance (the disease affects the majority of patients who inherit the gene), yet the presentation is extremely diverse. An individual suffering with NF-1 may exhibit all or none of the following symptoms.

A 54-Year-Old Man Visits His Doctor Complaining of New Onset