A 23-year-old woman comes to the physician for a routine health maintenance examination. She feels well. Menses have occurred at regular 30-day intervals and last for 5 days with normal flow. She has a history of gonorrhea that was treated at 20 years of age. She has smoked one pack of cigarettes daily for 3 years. She drinks one glass of wine daily. Her only medication is an oral contraceptive. Vital signs are within normal limits. Physical examination including pelvic examination shows no abnormalities. A Pap smear shows high-grade cervical intraepithelial neoplasia. Which of the following is the most likely finding on histopathology?

Question

A 23-year-old woman comes to the physician for a routine health maintenance examination. She feels well. Menses have occurred at regular 30-day intervals and last for 5 days with normal flow. She has a history of gonorrhea that was treated at 20 years of age. She has smoked one pack of cigarettes daily for 3 years. She drinks one glass of wine daily. Her only medication is an oral contraceptive. Vital signs are within normal limits. Physical examination including pelvic examination shows no abnormalities. A Pap smear shows high-grade cervical intraepithelial neoplasia.  Which of the following is the most likely finding on histopathology?

Quizplus · Accepted Answer

Eductional Objective: Human papillomavirus infection of basal cervical cells can progress to premalignant and cancerous lesions.  Cervical intraepithelial neoplasia refers to atypical squamous cells and is classified as low-grade squamous intraepithelial lesions (if extending <1/3 of the epithelium) or high-grade squamous intraepithelial lesions (if extending beyond).  Basement membrane breach signifies invasive disease.

A 23-Year-Old Woman Comes to the Physician for a Routine