A 62-year-old man arrives at the office for a jaundice evaluation. Medical history is important in the case of uncontrolled type 2 diabetes and morbid obesity. He does not smoke, drink, or use illegal drugs. There is no history of liver illness in the family. The vital indicators are within normal ranges. The average BMI is 47 kg/m². There is mild scleral icterus. Normal heart and lung sounds The abdomen is not painful or swollen. There is some bilateral lower extremities edema. Transaminases are shown to be increased in laboratory tests. A liver biopsy is performed, and trichrome staining reveals: Which of the following cells is directly responsible for the histologic finding indicated by the arrow?

Question

Quizplus · Accepted Answer

Eductional Objective: The principal cells involved in hepatic fibrosis are stellate (Ito) cells. Stellate cells are triggered in response to hepatic damage and change into myofibroblasts capable of multiplying, encouraging chemotaxis, and generating enormous amounts of collagen. The Masson trichrome stain turns collagen blue.

A 62-Year-Old Man Arrives at the Office for a Jaundice