Due to severe face puffiness, an 8-year-old child is brought to the doctor. His mother adds that he has been easily exhausted and has had black urine for the previous 24 hours. The patient had a skin infection three weeks ago and has no chronic medical issues. The temperature is 36.1 degrees Celsius (97 degrees Fahrenheit), and the blood pressure is 140/94 mm Hg. Periorbital edema and moderate pitting edema around the ankles are seen on physical examination. The rest of the test reveals no abnormalities. The picture below depicts a representative kidney biopsy sample. The fluorescent areas on the slide most likely indicate the presence of which of the following substances?

Question

Due to severe face puffiness, an 8-year-old child is brought to the doctor. His mother adds that he has been easily exhausted and has had black urine for the previous 24 hours. The patient had a skin infection three weeks ago and has no chronic medical issues. The temperature is 36.1 degrees Celsius (97 degrees Fahrenheit), and the blood pressure is 140/94 mm Hg. Periorbital edema and moderate pitting edema around the ankles are seen on physical examination. The rest of the test reveals no abnormalities. The picture below depicts a representative kidney biopsy sample.  The fluorescent areas on the slide most likely indicate the presence of which of the following substances?

Quizplus · Accepted Answer

Eductional Objective: Poststreptococcal glomerulonephritis is more frequent in children and manifests as a nephritic syndrome (eg, renal failure, hypertension, hematuria with red blood cell casts) 2-4 weeks after being infected with group A beta-hemolytic Streptococcus. Immunofluorescence microscopy reveals granular IgG, IgM, and C3 deposits in the mesangium and basement membranes.

Due to Severe Face Puffiness, an 8-Year-Old Child Is Brought