A 43-year-old man arrives to the office complaining of shortness of breath and exhaustion. His weariness has been so severe over the previous two weeks that he has "little energy, even to get out of bed." The patient has no chills but has recently gained weight and had ankle edema. He has no previous medical issues and does not use any drugs. The blood pressure is 168/94 mm Hg, and the pulse rate is 95 beats per minute. The patient has bilateral pitting edema of the lower extremities that is localized to the ankles. Urinalysis showed 2+ protein, 5-7 white blood cell count/hpf, and 75-100 red blood cell count/hpf. He had a kidney biopsy, and the results of immunofluorescent microscopy are displayed in the figure below. Which of the following would be the most likely finding on light microscopy in this patient?

Question

A 43-year-old man arrives to the office complaining of shortness of breath and exhaustion. His weariness has been so severe over the previous two weeks that he has "little energy, even to get out of bed." The patient has no chills but has recently gained weight and had ankle edema. He has no previous medical issues and does not use any drugs. The blood pressure is 168/94 mm Hg, and the pulse rate is 95 beats per minute. The patient has bilateral pitting edema of the lower extremities that is localized to the ankles. Urinalysis showed 2+ protein, 5-7 white blood cell count/hpf, and 75-100 red blood cell count/hpf. He had a kidney biopsy, and the results of immunofluorescent microscopy are displayed in the figure below.  Which of the following would be the most likely finding on light microscopy in this patient?

Quizplus · Accepted Answer

Eductional Objective: Anti-glomerular basement membrane (GBM) antibodies bind to collagen type IV, resulting in fast progressing glomerulonephritis with glomerular crescent development visible under a microscope. Characteristic immunofluorescence demonstrates linear deposits of IgG and C3 along the GBM.

A 43-Year-Old Man Arrives to the Office Complaining of Shortness