A 55-year-old man is brought to the physician because of inappropriate behavior for the past 6 months. He has been making inappropriate comments and jokes while talking to friends and family members. He was arrested 3 weeks ago while trying to kiss strangers on the street. He also has lost interest in talking to his daughter or playing with his grandchildren. During this period, he has developed a strong desire for chocolate pudding and potato chips and has gained 10 kg (22 lb). He appears unkempt. Vital signs are within normal limits. Physical examination is unremarkable. Mental status examination shows apathy and a blunt affect. This patient's condition is most likely due to abnormal accumulation of which of the following?

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Quizplus · Accepted Answer

Eductional Objective: Frontotemporal dementia presents with early personality change, executive dysfunction, compulsivity, and hyperorality.  It is associated with neurofibrillary tangles due to abnormal tau proteins (also seen in Alzheimer dementia) and pathologically ubiquitinated TDP-43 (also seen in amyotrophic lateral sclerosis).

A 55-Year-Old Man Is Brought to the Physician Because of Inappropriate