A 48-Year-Old Woman Arrives at the Office with a Sore

A 48-year-old woman arrives at the office with a sore throat that has been bothering her for three months. She has an enlarged, ulcerated left tonsil and a firm, nontender, nonmobile left neck mass on examination. A tonsil biopsy is performed on the patient. The pathology points to squamous cell carcinoma. Further examination of the biopsy specimen reveals the presence of viral genome proteins.Which of the following most likely predisposed the patient to the development of this malignancy?

A) Decreased activity of BRAF-associated protein
B) Decreased activity of RB-associated protein
C) Decreased activity of RET-associated protein
D) Overexpression of BRCA1- or BRCA2-associated protein
E) Overexpression of MEN1-associated protein