A 51-year-old woman comes to the physician because of fatigue and progressive pain and stiffness in her hands for the past 3 months. She used to play tennis but stopped 1 month ago because of difficulties holding the racket and her skin becoming "very sensitive to sunlight." Her last menstrual period was 1 year ago. She has diabetes mellitus controlled with insulin. She does not smoke or drink alcohol. Vital signs are within normal limits. Physical examination shows generalized hyperpigmentation. The second and third metacarpophalangeal joints of both hands are tender to palpation and the range of motion is limited. Which of the following is the most likely diagnosis?

Question

Quizplus · Accepted Answer

Eductional Objective: Hereditary hemochromatosis is an autosomal recessive disease characterized by excessive gastrointestinal absorption of iron, which is then stored as hemosiderin in various tissues.  Secondary arthritis is common and typically involves the second and third metacarpophalangeal joints.  Other manifestations include liver disease, skin hyperpigmentation, diabetes mellitus, pituitary hormone deficiencies (eg, central hypogonadism), and cardiomyopathy.

A 51-Year-Old Woman Comes to the Physician Because of Fatigue