A 29-year-old woman is evaluated for severe left hip pain after twisting her leg. She has bony deformities of the lower extremities, and her mobility is limited. The patient has a history of hyperthyroidism, which was managed with radioiodine therapy. Menarche was at age 7, and she has regular 30-day cycles. Physical examination shows large, hyperpigmented macules with irregular borders located on the left shoulder, left side of the neck, and left buttock. X-ray findings are shown in the image below. Which of the following is the most likely diagnosis?

Question

A 29-year-old woman is evaluated for severe left hip pain after twisting her leg.  She has bony deformities of the lower extremities, and her mobility is limited.  The patient has a history of hyperthyroidism, which was managed with radioiodine therapy.  Menarche was at age 7, and she has regular 30-day cycles.  Physical examination shows large, hyperpigmented macules with irregular borders located on the left shoulder, left side of the neck, and left buttock.  X-ray findings are shown in the image below.  Which of the following is the most likely diagnosis?

Quizplus · Accepted Answer

Eductional Objective: McCune-Albright syndrome is characterized by the triad of fibrous dysplasia of the bone, endocrine abnormalities, and café-au-lait spots. The condition results from an activating mutation in the G protein/CAMP/adenylate cyclase signaling pathway.

A 29-Year-Old Woman Is Evaluated for Severe Left Hip Pain