A 40-year-old man comes to the office due to several months of abdomen discomfort and crampsHe also reports a progressive itching after showers and rash which is increased after scratching. He has feels fatigue all the time and he is frequently dizzy and light-headed after prolonged standing. He has no prior medical conditions and takes no medictions The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are normal. Skin examination shows a maculopapular rash. Skin biopsy shows large clusters of mast cells that are positive for KIT (CD 117). Which of the following additional findings are most likely present in this patient?

Question

A 40-year-old man comes to the office due to several months of abdomen discomfort and crampsHe also reports a progressive itching after showers and rash which is increased after scratching. He has feels fatigue all the time and he is frequently dizzy and light-headed after prolonged standing. He has no prior medical conditions and takes no medictions The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are normal.  Skin examination shows a maculopapular rash.  Skin biopsy shows large clusters of mast cells that are positive for KIT (CD 117).  Which of the following additional findings are most likely present in this patient?

Quizplus · Accepted Answer

Eductional Objective: Systemic mastocytosis is characterized by the abnormal proliferation of mast cells and increased histamine release.  Histamine causes hypersecretion of gastric acid by parietal cells in the stomach as well as a variety of other symptoms (eg, hypotension, flushing, pruritus).

A 40-Year-Old Man Comes to the Office Due to Several