You are interested in identifying the role of genetic factors in alcoholism. A case-control study is done of patients with alcoholism and age- and sex-matched controls. After DNA is obtained, the alcohol dehydrogenase-3 gene is analyzed for a common genetic polymorphism. The frequency of the polymorphism is found to be significantly higher among cases than controls. The polymorphism results in a silent amino acid substitution, and functional studies indicate that the variant and the normal allele have similar activity. How do you interpret your finding?

Question

Quizplus · Accepted Answer

The Answer of You are interested in identifying the role of genetic factors in alcoholism. A case-control study is done of patients with alcoholism and age- and sex-matched controls. After DNA is obtained, the alcohol dehydrogenase-3 gene is analyzed for a common genetic polymorphism. The frequency of the polymorphism is found to be significantly higher among cases than controls. The polymorphism results in a silent amino acid substitution, and functional studies indicate that the variant and the normal allele have similar activity. How do you interpret your finding?

You Are Interested in Identifying the Role of Genetic Factors