Which of the following diagnostic criteria is true in individuals

Question

Which of the following diagnostic criteria is true in individuals <20 years old with features of Marfan syndrome but do not meet diagnostic criteria?

Quizplus · Accepted Answer

Additional clinical features may emerge in individuals under the age of 20. Therefore, special considerations to diagnostic criteria should be taken in trying to diagnose an individual who is under the age of 20. This makes answer choice A incorrect since it is important that features may emerge after the age of 20 and those who may not meet diagnostic criteria but do have some features should still be followed for emerging signs of the syndrome past the age of 20. Answer choice B is correct. It explains that although an individual does not have cardiovascular involvement at that particular time, they are still susceptible to involvement if they have Marfan syndrome. Answer choice C is incorrect because an FBN1 mutation alone is not diagnostic. Answer choice D is also incorrect because although someone does not meet diagnostic criteria at a particular point in time they may do so later and especially if there is familial history.

Which of the Following Diagnostic Criteria Is True in Individuals