This cytokine, although used to treat some forms of cancer, can induce severe depression:

Question

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Interferon-α is known to be used in the treatment of certain cancers, such as melanoma and hepatitis C, but it has been associated with inducing severe depression in some patients. This side effect is significant enough that patients undergoing treatment with interferon-α are often monitored for changes in mood and mental health.

This Cytokine, Although Used to Treat Some Forms of Cancer