Once a benzodiazepine is absorbed, the rate at which it reaches its site of action depends on which of the following? (Select all that apply.)

Question

Quizplus · Accepted Answer

Lipid solubility affects how easily a drug can cross cell membranes to reach its site of action. Protein binding influences the amount of free drug available to exert its effect. Ionization affects the drug's ability to cross cell membranes, as non-ionized drugs cross more easily. The FDA pregnancy category and first-order kinetics do not directly influence the rate at which a drug reaches its site of action.

Once a Benzodiazepine Is Absorbed, the Rate at Which It