Matching
The block in the stage of lymphocyte development described in questions , will be caused by a mutation in which of the genes listed (A-F)?
-CD4+CD8+ thymocyte to single positive CD8+ thymocyte

Question

Quizplus · Accepted Answer

Maturation to a single positive CD8⁺ thymocyte requires positive selection of cells whose TCRs recognize self class I MHC-peptide complexes on other cells in the thymus
TAP-1 and TAP-2 are needed to deliver peptides that participate in the assembly of class I-peptide complexes into the endoplasmic reticulum
Mutations in RAG-2, Ikaros, CD3e, or JAK3 would block development before the double positive thymocyte stage.

Matching the Block in the Stage of Lymphocyte Development Described in in Questions