For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
-A protein that is expressed only in immunologically privileged tissue
A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Question

Quizplus · Accepted Answer

Some tumor antigens are derived from genes that are silent in most tissues
The proteins encoded by many of these genes are not mutated and are not required for malignant transformation
However, they do act as tumor antigens and can elicit immune responses
Melanoma antigen (MAGE) is a cellular protein antigen recognized by tumor-specific cytolytic T lymphocyte clones derived not only from melanomas but also from carcinomas of the bladder, breast, skin, lung, and prostate
However, among normal tissues, MAGE expression is restricted to the testis, an immunologically privileged site that prevents the development of immune tolerance to this protein.

For Each Description in Questions , Choose the Tumor Antigen