For each of the descriptions in questions , select the tumor immunotherapy strategy (A-J) that is best match.
-Therapy that targets an antigen that is not essential to the malignant phenotype of the tumor; antigen-loss variants can emerge during therapy
A)Killed tumor vaccine
B)DNA vaccines
C)Interleukin (IL)-2
D)IL-4
E)GM-CSF (granulocyte-macrophage colony-stimulating factor)
F)Anti-CD3 antibodies
G)Lymphokine-activated killer cells
H)Anti-Her2/neu antibodies
I)Anti-idiotypic antibodies
J)Dendritic cell vaccine

Question

Quizplus · Accepted Answer

Malignant tumors of B lymphocytes often express a membrane Ig; because they are clonal, all the tumor cells express the same Ig with the same idiotype
Therefore, the idiotype on these tumors is a very specific tumor antigen
Antiidiotypic antibodies have been used to treat these tumors, but often, the therapy "selects" for cells that no longer express the idiotype
Because the idiotype is not necessary for the malignant phenotype, the antigen-loss variants will continue to grow.
Multiple Choice

For Each of the Descriptions in Questions , Select the Tumor