An arginine residue and a phenylalanine residue are located close to each other in a protein structure.
Select the most favorable interaction(s) of arginine and phenylalanine.

Question

An arginine residue and a phenylalanine residue are located close to each other in a protein structure.
 Select the most favorable interaction(s) of arginine and phenylalanine.

Quizplus · Accepted Answer

The pi-cation interaction is the most favorable interaction between an arginine residue and a phenylalanine residue. This interaction occurs when the aromatic ring of the phenylalanine interacts with the positively charged guanidinium group of arginine. This interaction is commonly observed in protein-protein and protein-ligand interactions. Offset stacking and edge-to-face interactions are less favorable and occur between aromatic residues.

An Arginine Residue and a Phenylalanine Residue Are Located Close