The following represents a signal transduction cascade initiated by double-stranded DNA damage and ending with activation of apoptosis by the BH3-only proteins PUMA and Noxa.
Double-stranded DNA damage; Chk2; _______; PUMA/Noxa; apoptosis.
Which protein belongs in the blank?

Question

Quizplus · Accepted Answer

After double-stranded DNA damage, Chk2 phosphorylates and activates p53. Activated p53 can transcriptionally activate the BH3-only proteins PUMA and Noxa which then promote apoptosis. Therefore, p53 is the protein that belongs in the blank.

The Following Represents a Signal Transduction Cascade Initiated by Double-Stranded