TNF and related cytokines can directly induce apoptosis. Which statement about TNF-mediated induction of apoptosis is true?
A) TNF binds a trimeric receptor complex on the surface of the cell membrane.
B) Upon receptor binding, caspase-8 is activated through an adaptor protein.
C) Caspase-8 activates Bid, which in turn activates Bax and Bak and then feeds into the mitochondrial pathway.
D) All of the above statements are true.
Correct Answer:
Verified
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