Which Experimental Evidence Was Not Useful in the Search for a Link

Which experimental evidence was not useful in the search for a link between histone acetylation and gene activation?

A) A Tetrahymena histone acetyltransferase was found to be homologous to a known transcriptional activator in yeast.
B) A mammalian histone deacetylase was found to be homologous to a known transcriptional repressor in yeast.
C) The expression of a gene for a known transcriptional activator from yeast produced a protein that had high levels of histone acetyltransferase activity.
D) Chemical analysis of acetylated histones showed that the acetyl groups were added to lysine residues.