The typical pattern of tangles in Alzheimer's disease follows which pattern?
A) Entorhinal cortex → hippocampus → neocortex
B) Neocortex → entorhinal cortex → hippocampus
C) Basal forebrain → entorhinal cortex → hippocampus → neocortex
D) None of the above; degeneration occurs primarily in cholinergic and monoaminergic systems, not brain regions.
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