Which of the following supports the neurotrophic hypothesis of depression?
A) The loss of dendritic branches and spines in the hippocampus and PFC and reduced neurogenesis in the hippocampus may be due to low BDNF.
B) Acute antidepressant treatment increases BDNF in both animals and humans.
C) Chronic stress increases BDNF in the hippocampus in rats.
D) BDNF is enhanced by upregulation in the cAMP cascade, as occurs with treatments for depression.
Correct Answer:
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