Chronic social defeat stress causes an increase in histone _______, which leads to a decrease in BDNF gene expression by tightening the structure of chromatin. Antidepressant treatment results in a(n) _______ and enhanced BDNF expression.
A) acetylation; decrease in histone acetylation
B) acetylation; increase in histone methylation
C) methylation; decrease in histone methylation
D) methylation; increase in histone acetylation
Correct Answer:
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