Endocannabinoids contribute to retrograde signaling in the hippocampus, Striatum, and cerebellum by A) blocking the reuptake transporters. B) blocking CB₁ autoreceptors on the presynaptic terminals. C) inhibiting Ca²⁺-mediated vesicular neurotransmitter release. D) activating CB₁ receptors and increasing GABA release.

Question

Quizplus · Accepted Answer

Endocannabinoids contribute to retrograde signaling primarily by inhibiting calcium-mediated vesicular neurotransmitter release. This occurs when endocannabinoids, produced and released by postsynaptic neurons, bind to cannabinoid receptors on presynaptic neurons, leading to a decrease in neurotransmitter release.

Endocannabinoids Contribute to Retrograde Signaling in the Hippocampus