A metabotropic glutamate receptor is located postsynaptically and mediates excitatory responses by stimulating the phosphoinositide second-messenger system. This receptor belongs in _______ and is either _______.
A) group I; mGluR1 or mGluR5
B) group 2; mGluR2 or mGluR3
C) group 3; mGluR4 or mGluR6
D) group 3; mGluR7 or mGluR8

Question

Quizplus · Accepted Answer

Metabotropic glutamate receptors (mGluRs) are classified into three groups: Group I (mGluR1 and mGluR5), Group II (mGluR2 and mGluR3), and Group III (mGluR4, mGluR6, mGluR7, and mGluR8). The receptor in question is located postsynaptically and mediates excitatory responses by stimulating the phosphoinositide second-messenger system, which is characteristic of Group I mGluRs, specifically mGluR1 and mGluR5. Therefore, the best choice is A.

A Metabotropic Glutamate Receptor Is Located Postsynaptically and Mediates Excitatory