Which event does not have to occur for NMDA receptor channel opening?
A) An excitatory amino acid like glutamate must bind to the receptor.
B) The PCP block must be removed.
C) A co-agonist must bind at the glycine site.
D) The membrane must be depolarized by some other receptor.

Question

Quizplus · Accepted Answer

PCP (phencyclidine) is a non-competitive antagonist that blocks the NMDA receptor channel. Its removal is not necessary for NMDA receptor channel opening. However, binding of an excitatory amino acid (like glutamate), a co-agonist (like glycine), and depolarization of the membrane by another receptor are all necessary events for NMDA receptor channel opening.

Which Event Does Not Have to Occur for NMDA Receptor