The _______ theory holds that the loss of FMRP causes exaggerated group I mGluR-related functions, including dendritic spine abnormalities and elevated long-term depression which result in the symptoms of FXS.
A) ionotropic glutamate receptor
B) metabotropic glutamate receptor
C) fragile X receptor
D) mGluR5

Question

Quizplus · Accepted Answer

The correct answer is the metabotropic glutamate receptor theory. This theory suggests that the absence of the Fragile X Mental Retardation Protein (FMRP) leads to an overactivation of metabotropic glutamate receptor (mGluR) pathways, particularly group I mGluRs, which in turn causes the neurological symptoms observed in Fragile X Syndrome (FXS), including dendritic spine dysmorphogenesis and enhanced long-term depression.

The _______ Theory Holds That the Loss of FMRP Causes