The most important difference between pyridostigmine and sarin is that
A) pyridostigmine is an irreversible AChE inhibitor; sarin is not.
B) Pyridostigmine does not cross the blood-brain barrier; sarin does.
C) sarin is an irreversible AChE inhibitor; pyridostigmine is not.
D) pyridostigmine is isolated from Calabar beans; sarin is not.

Question

Quizplus · Accepted Answer

Sarin is an irreversible acetylcholinesterase (AChE) inhibitor, meaning it permanently binds to and inactivates the enzyme, leading to an accumulation of acetylcholine in the synaptic cleft and continuous stimulation of muscles, glands, and the central nervous system. Pyridostigmine, on the other hand, is a reversible AChE inhibitor used in the treatment of myasthenia gravis and as a prophylactic against nerve gas attacks. It temporarily inhibits the enzyme, allowing for controlled increases in acetylcholine levels.

The Most Important Difference Between Pyridostigmine and Sarin Is That